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冯杜

发布日期:2023-03-17    作者:     来源:    点击:

个人概况

姓名 冯杜 性别:男

职称: 教授 导师资格:博导、硕导

单位:基础医学院/呼吸疾病国家重点实验室

学历:博士 毕业院校:博士,清华大学/博士后,哈佛大学

招生专业 病理学与病理生理学

电子邮件 fenglab@gzhmu.edu.cn

通信地址 广州医科大学番禺校区A1-604


研究方向

线粒体作为真核细胞内具有遗传物质的重要细胞器,除给机体生命活动供能外,还参与钙稳态、氧化应激、细胞死亡、信号转导等众多细胞关键事件。但随着机体老化、在环境刺激、化学毒性、病理胁迫等条件下,受损线粒体若不及时清除、过氧化物过多积累将导致神经变性疾病、癌症等一系列的疾病的发生,严重威胁人类健康,而线粒体自噬是通过将受损或多余的线粒体运送到自噬溶酶体中降解、清除的过程,阐明线粒体自噬的机理对于人们理解线粒体自噬相关疾病的发生、发展意义重大。但2010年以前,人们对于这一重要过程的分子调控机制并不明确。

课题组从2010年开始,聚焦细胞自噬领域,开展研究工作11年,主攻细胞器选择性自噬的分子机理及生理功能。研究内容系统、连续,2012年以来,在线粒体自噬领域取得系列研究成果,作出系统性贡献。申请人已发表学术论文49篇,第一或通讯作者文章25篇(其中通讯作者21篇),包括Nature Cell Biology2012)、EMBO Reports (2014)The EMBO Journal (20162022)Mol Psychiatry (2023) Autophagy (2021)等权威学术期刊,发表文章总影响因子>310,总被引次数>16500次(Google scholar)。研究工作受到CellNature Reviews Molecular Cell BiologyThe EMBO JTrends in cell biologyJ Cell BioFaculty 1000等国际期刊专题评论和推荐,产生了重要的学术影响。 多次以主席身份组织国内会议并在国内外重要学术会议作邀请报告,为The EMBO Journal, Autophagy, JBCJCSCell Death & DifferentiationAdvanced ScienceNature Communications30余个国际权威杂志审稿人。


所获荣誉

1. 2018年入选广东省珠江学者特聘教授、2019年入选广州市优秀专家

2. 2015年入选广东省扬帆计划拔尖人才

指导学生获得的科研项目和奖项

1. 第八届全国大学生基础医学创新研究暨实验设计论坛全国总决赛 金奖1

2. 第八届全国大学生基础医学创新研究暨实验设计论坛全国总决赛 银奖1

社会兼职

1. 任中国病理生理学会蛋白质修饰与疾病分委会委员、青年委员会主任

2. 中国生物物理学会线粒体分会理事

主持科研项目

1. 项目名称:国家自然科学基金重大研究计划集成项目,细胞器互作在自噬过程中的作用及机制,项目编号:92254307,总经费 830万,分课题负责人 150万,20231-202612

2. 称:国家自然科学基金面上项目,“营养匮乏条件下哺乳动物细胞中核糖体自噬新受体的鉴定及其功能研究 项目编号:32170758,经费:58万,项目主持人(排名1)起 间:20221-202512

3. 称:国家自然科学基金重大研究计划(培育项目)细胞器膜蛋白ATP9A基因突变导致人遗传性智力障碍的作用机制研究,项目编号:91754115,经费:70万,项目主持人(排名1)起 间:20181-202012

4. 称:国家自然科学基金面上项目“AMPKMFN2相互作用及其生物学功能,项目编号:31771531,经费:61万元,项目主持人(排名1),起止时间:201801-202112

5. 称:国家自然科学基金青年基金自噬关键激酶ULK1 及其新底物FUNDC1 共同调节线粒体自噬的机制研究,项目编号:31401182,经费:25 万元,项目主持人(排名1);起 间:20151-201712

6. 称:广东省引进紧缺拔尖扬帆计划人才项目,广东省委组织部,项目编号:4YF14007G,经费:100 万元,项目主持人(排名1);起 间:2015 1 -2017 12

7. 称:广东省科技计划项目:灵长类动物脊髓损伤模型制备与评价体系的建立,广东省科技厅,项目编号:2017B090901051,经费:100万元,项目主持人(排名1);起止时间:20121-201912

8. 项目名称:科技部973 国家重大基础研究计划胁迫环境中自噬--溶酶体通路与细胞代谢调控机制”,项目编号:2013CB910100,经费:42 万元;项目骨干, 间:2013 -2017

9. 称:广东省自然科学基金“AMPK ULK1 在低氧诱导线粒体自噬过程中的协同调节机制,项目编号:2014A030313533,经费:10 万元,项目主持人(排名1);起止时间:2015 1 -2017 12

10. 称:广东省公益研究基金项目肿瘤低氧微环境中miR-93 调控ULK1 的自噬功能研究,项目编号:2016A020215152,经费:10 万元,项目主持人(排名1);起止时间:2015 1 -2017 12

11. 项目名称:广州市岭南英杰工程后备人才,经费:125万,项目主持人,起止时间:2018-2022

部分代表性第一和通讯作者论文

[1] Liu H#, Fan H#, He P#, Zhuang H, Liu X, Chen M, Zhong W, Zhang Y, Zhen C, Li Y, Jiang H, Meng T, Xu Y, Zhao G, Feng D* Prohibitin 1 regulates mtDNA release and downstream inflammatory responses.

EMBO J. 2022 Oct 17;e111173. doi: 10.15252/embj.2022111173. 影响因子:14.3

[2] Meng T#, Chen XT#, He ZJ, Huang HF, Lin SY, Liu KR, Bai G, Xu MD, Zhuang HX, Zhang YL, Waqas A, Liu Q, Zhang C, Sun XD, Huang HS, Umair M*, Yan YS*, Feng D*. ATP9A Deficiency Causes ADHD and Aberrant Endosomal Recycling via Modulating RAB5 and RAB11 Activity.

Molecular Psychiatry 2023 Jan 6;1-13. doi: 10.1038/s41380-022-01940-w. 影响因子:13.4

[3] Hu Y#, Chen H#, Zhang L#, Lin X#, Li X, Zhuang H, Fan H, Meng T, He Z, Huang H, Gong Q, Zhu D, Xu Y, He P, Li L, Feng D*. The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses.

Autophagy. 2021 May;17(5):1142-1156. 影响因子:13.4

[4] Phadwal K, Feng D*, Zhu D*, MacRae VE. Autophagy as a novel therapeutic target in vascular calcification.

Pharmacol Ther. 2019 Oct 21:107430. doi:10.1016/j.pharmthera.2019.107430. 影响因子:13.4

[5] Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, Zhuang H, Zhang X, Chen H, Li S, Yang Y, Lu Y, Wang J, Zhu R, Zhang L, Sui S, Tan N, Zhao B*, Zhang J*, Li L*, Feng D*. FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.

EMBO J. 2016 Jul 1;35(13):1368-84. 影响因子:14

[6] Wu W#, Tian W#, Hu Z, Chen G, Huang L, Li W, Zhang X, Xue P, Zhou C, Liu L, Zhu Y, Zhang X, Li L, Zhang L, Sui S, Zhao B*, Feng D*. ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy.

EMBO Rep. 2014 May;15(5):566-75. 影响因子:9.07

[7] Liu Y#, Liu H#, Li Z#, Fan H#, Yan X, Liu X, Xuan J, Feng D*, Wei X*. The Release of Peripheral Immune Inflammatory Cytokines Promote an Inflammatory Cascade in PCOS Patients via Altering the Follicular Microenvironment.

Front Immunol 2021 May 17 doi: 10.3389/fimmu.2021.685724. 影响因子:7.562

[8] Li W#, Zhang X#, Zhuang H#, Chen HG, Chen Y, Tian W, Wu W, Li Y, Wang S, Zhang L, Chen Y, Li L, Zhao B, Sui S, Hu Z*, Feng D*. MicroRNA-137 is a Novel Hypoxia-responsive MicroRNA that Inhibis Mitophagy via Regulation of Two Mitophagy Receptors FUNDC1 and NIX.

J Biol Chem. 2014 11;289(15):10691-701 影响因子:5.48

Faculty of 1000评论: http://f1000.com/prime/718289730

[9] Liu L#, Feng D#, Chen G#, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, Huang L, Xue P, Li B, Wang X, Jin H, Wang J, Yang F, Liu P, Zhu Y, Sui SF, Chen Q*. Mitochondrial outer membrane protein FUNDC1 mediates hypoxia-induced mitochondrial autophagy in mammalian cells.

Nature Cell Biology, 2012, 14(2):177-85. 影响因子:28.21

Nature杂志评论:

http://www.natureasia.com/en/nchina/article/10.1038/nchina.2012.15

Faculty of 1000评论: http://f1000.com/prime/14270957

[10] Lin S#, Meng T#, Huang H, Zhuang H, He Z, Yang H*, Feng D*. Molecular machineries and physiological relevance of ER-mediated membrane contacts.

Theranostics, 2021 Jan 1;11(2):974-995. doi: 10.7150/thno.51871. 影响因子:11.552

[11] Li W#, He P#, Huang Y#, Li YF#, Lu J, Li M, Kurihara H, Luo Z, Meng T, Onishi M, Ma C, Jiang L, Hu Y, Gong Q, Zhu D, Xu Y, Liu R, Liu L, Yi C, Zhu Y, Ma N, Okamoto K, Xie Z, Liu J, He RR*, Feng D*. Selective autophagy of intracellular organelles: recent research advances.

Theranostics. 2021 Jan 1;11(1):222-256. 影响因子:11.552

[12] Tian W#, Li W#, Chen Y, Yan Z, Huang X, Zhuang H, Zhong W, Chen Y, Wu W, Lin C, Chen H, Hou X, Zhang L, Sui S, Zhao B, Hu Z*, Li L*, Feng D*. Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy.

FEBS Lett. 2015, 8; 589(15):1847-54. 影响因子:3.46

[13] Chen Z, Hu Z, Lu Z, Cai S, Gu X, Zhuang H, Ruan Z, Xia Z, Irwin MG, Feng D*, Zhang L*. Differential MicroRNA Profiling in a Cellular Hypoxia Reoxygenation Model upon Posthypoxic Propofol Treatment Reveals Alterations in Autophagy Signaling Network.

Oxid Med Cell Long, 2013:378484. doi: 10.1155/2013/378484 影响因子:7.31

[14] Feng D#, Zhao WL#(#并列一作), Ye YY, Bai XC, Chang LF, Zhou Q, Sui SF*.

Cellular internalization of exosomes occurs through phagocytosis.

Traffic. 2010, 11(5):675-87. 影响因子:4.5

[15] Li W#, Yang Y#, Hou X#, Zhuang H, Wu Z, Li Z, Guo R, Chen H, Lin C, Zhong W, Chen Y, Wu K*, Zhang L*, Feng D*. MicroRNA-495 regulates starvation-induced autophagy by targeting ATG3. FEBS Lett. 2016 Feb 22. doi: 10.1002/1873-3468.12108. 影响因子:3.46

[16] Li W#, Yang Y#, Ba Z#, Li S, Chen H, Hou X, Ma L, He P, Jiang L, Li L, He R*, Zhang L*, Feng D*. MicroRNA-93 Regulates Hypoxia-Induced Autophagy by Targeting ULK1.

Oxid Med Cell Longev 2017;2017:2709053. doi: 10.1155/2017/2709053. 影响因子:7.31

[17] Feng D, Liu L, Zhu Y, Chen Q*. Molecular Signaling towards mitophagy and its physiological significance.

Exp Cell Res. 2013 Jul 15; 319(12):1697-705. (特邀综述)影响因子:3.5

[18] Zhuang H, Tian W, Li W, Zhang X, Wang J, Yang Y, Liu X, Xia Z, Feng D*, Zhang L*. Autophagic Cell Death and Apoptosis Jointly Mediate Cisatracurium Besylate-Induced Cell Injury.

Int J Mol Sci. 2016 Apr 6;17(4). 影响因子:6.2

[19] Zhang F#, Sun S#, Feng D#(#并列一作), Zhao WL, Sui SF*. A novel strategy for the invasive toxin: hijacking exosome-mediated intercellular trafficking.

Traffic. 2009, 10:411-424. 影响因子:4.5

[20] Chen J, Chen X, Xu D, Yang L, Yang Z, Yang Q, Yan D, Zhang P, Feng D*, Liu J*. Autophagy Induced by Proteasomal DUB Inhibitor NiPT Restricts NiPT-Mediated Cancer Cell Death.

Front Oncol. 2020 Mar 27;10:348. doi: 10.3389/fonc.2020.00348. eCollection 2020. 影响因子:5.738

[21] Fan H, He Z, Huang H, Zhuang H, Liu H, Liu X, Yang S, He P, Yang H*, Feng D*. Mitochondrial Quality Control in Cardiomyocytes: A Critical Role in the Progression of Cardiovascular Diseases.

Front Physiol. 2020 Mar 27;11:252. doi: 10.3389/fphys.2020.00252.eCollection 2020. 影响因子:4.755

合作文章

[1] Zhao YG, Chen Y, Miao G, Zhao H, Qu W, Li D, Wang Z, Liu N, Li L, Chen S, Liu P, Feng D, Zhang H*.

The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

Mol Cell. 2017 Sep 21;67(6):974-989. 影响因子:15.4

[2] Zhou C, Ma K, Gao R, Mu C, Chen L, Liu Q, Luo Q, Feng D, Zhu Y, Chen Q. Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy.

Cell Res. 2017 Feb;27(2):184-201. 影响因子:46.29

[3] Wang Z, Miao G, Xue X, Guo X, Yuan C, Wang Z, Zhang G, Chen Y, Feng D, Hu J, Zhang H*.

The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes.

Mol Cell. 2016 Sep 1;63(5):781-95影响因子:15.4

[4] Chen G#, Han Z#, Feng D, Chen Y, Chen L, Wu H, Huang L, Zhou C, Cai X, Fu C, Duan L, Wang X, Liu L, Liu X, Shen Y, Zhu Y, Chen Q*. A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy.

Mol Cell. 2014, 8;54(3):362-77. 影响因子:15.4

[5] Zhao H, Zhao YG, Wang X, Xu L, Miao L, Feng D, Chen Q, Kovács AL, Fan D, Zhang H*.

Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration.

J Cell Biol. 2013, 18;200(6):731-41. 影响因子:10.2

[6] Yue W, Chen Z, Liu H, Yan C, Chen M, Feng D, Yan C, Wu H, Du L, Wang Y, Liu J, Huang X, Xia L, Liu L, Wang X, Jin H, Wang J, Song Z, Hao X*, Chen Q*. A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30.

Cell Res. 2014 Feb 11. doi: 10.1038/cr.2014.20. 影响因子:46.29

[7] Guo B, Huang J, Wu W, Feng D, Wang X, Chen Y, Zhang H. The nascent polypeptide-associated complex is essential for autophagic flux.

Autophagy. 2014 Oct 1;10(10):1738-48. 影响因子:11.7

[8] Guo B, Liang Q, Li L, Hu Z, Wu F, Zhang P, Ma Y, Zhao B, Kovács AL, Zhang Z, Feng D, Chen S, Zhang H. O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation.

Nat Cell Biol. 2014, 16(12):1215-26 影响因子:20.8

[9] Li J, Qi W, Chen G, Feng D, Liu J, Ma B, Zhou C, Mu C, Zhang W, Chen Q, Zhu Y. Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy.

Autophagy. 2015;11(8):1216-29. 影响因子:11.7

[10] Liu RQ, Zhou QH, Ji SR, Zhou Q, Feng D, Wu Y, Sui SF*. Membrane localization of beta-amyloid 1-42 in lysosomes: a possible mechanism for lysosome labilization.

J Biol Chem. 2010, 285(26):19986-96. 影响因子:4.6

[11] Zhao W, Feng D, Sun S, Han T, Sui S. The anti-viral protein of trichosanthin penetrates into human immunodeficiency virus type 1.

Acta Biochim Biophys Sin (Shanghai). 2010 Feb;42(2):91-7. 影响因子:2.191

[12] Zhao WL, Zhang F, Feng D, Wu J, Chen S, Sui SF. A novel sorting strategy of trichosanthin for hijacking human immunodeficiency virus type 1.

Biochem Biophys Res Commun. 2009 Jul 3;384(3):347-51. 影响因子:2.4

Zhao WL, Feng D, Wu J, Sui SF. Trichosanthin inhibits integration of human immunodeficiency virus type 1 through depurinating the long-terminal repeats.

Mol Biol Rep. 2010 Apr;37(4):2093-8. 影响因子:2.02

[13] Li H, Liu Q, Hu X, Feng D, Xiang S, He Z, Hu X, Zhou J, Ding X, Zhou C, Zhang J. Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator.

Acta Biochim Biophys Sin (Shanghai). 2009 Jul;41(7):535-44. 影响因子:2.19

[14] Ding X, Fan C, Zhou J, Zhong Y, Liu R, Ren K, Hu X, Luo C, Xiao S, Wang Y, Feng D, Zhang J. GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation.

Nucleic Acids Res. 2006 May 12;34(9):2570-8. 影响因子:9.1

[15] Ma Q, Zhu C, Zhang W, Ta N, Zhang R, Liu L, Feng D, Cheng H, Liu J, Chen Q.

Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway. Cell Death Differ. 2018 May 21. doi: 10.1038/s41418-018-0121-8.

[16] Fu Y, Huang Z, Hong L, Lu JH, Feng D, Yin XM, Li M. Targeting ATG4 in Cancer Therapy.

Cancers (Basel). 2019 May 10;11(5). pii: E649. doi: 10.3390/cancers11050649. Review.

[17] Li D, Zhao YG, Li D, Zhao H, Huang J, Miao G, Feng D, Liu P, Li D, Zhang H.The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation.

Cell Rep. 2019 Apr 9;27(2):343-358.e5.

[18] Dong Y, Hu Y, Sarkar S, Zong WX, Li M, Feng D, Song JX, Li M, Medina DL, Tan J, Zhang Z, Yue Z, Lu JH. Autophagy modulator scoring system: a user-friendly tool for quantitative analysis of methodological integrity of chemical autophagy modulator studies.

Autophagy. 2019 Dec 23:1-8. doi: 10.1080/15548627.2019.1704119. 影响因子:11.7

[19] Guo S, Li A, Fu X, Li Z, Cao K, Song M, Huang S, Li Z, Yan J, Wang L, Dai X, Feng D, Wang Y, He J, Huo Y, Xu Y*. Gene-dosage effect of Pfkfb3 on monocyte/macrophage biology in atherosclerosis.

Br J Pharmacol. 2022 Nov;179(21):4974-4991

[20] Yan J, Li A, Chen X, Cao K, Song M, Guo S, Li Z, Huang S, Li Z, Xu D, Wang Y, Dai X, Feng D, Huo Y, He J, Xu Y*. Glycolysis inhibition ameliorates brain injury after ischemic stroke by promoting the fnction of myeloid-derived suppressor cells.

Pharmacol Res. 2022 May;179:106208. doi: 10.1016/j.phrs.2022.106208.harm

[21] Wu MY, Wang EJ, Feng D, Li M, Ye RD, Lu JH*. Pharmacological insights into autophagy modulation in autoimmune diseases.

Acta Pharm Sin B. 2021 Nov;11(11):3364-337

英文专著

[1] Exploring MicroRNAs on NIX-Dependent Mitophagy.

Li W, Chen H, Li S, Lin G, Feng D*.

Methods Mol Biol. 2017 Mar 24. doi: 10.1007/7651_2017_15

[2] Immunofluorescence Staining Protocols for Major Autophagy Proteins Including LC3, P62, and ULK1 in Mammalian Cells in Response to Normoxia and Hypoxia.

Li W, Li S, Li Y, Lin X, Hu Y, Meng T, Wu B, He R, Feng D*.

Methods Mol Biol. 2019;1854:175-185. doi: 10.1007/7651_2018_124.