个人概况：宣爱国，男，博士，教授，博士后合作导师、博士生导师，南山学者。广东省优秀青年教师培养对象，广东省“千百十工程”培养对象，广州市高层次人才，国家重大科技培育项目、国家自然科学基金评审专家，博士毕业于南方医科大学，师从于高天明院士。
研究兴趣：神经发育异常与认知障碍的关系及其机制的研究，着重围绕表观遗传学修饰与神经元再生、神经退行性疾病发生的关系等方面展开基础研究。近年主持国家自然科学基金2项及13项省市厅级课题。
电子邮件：xag2005@163.com
近五年部分代表性通讯作者论文：
1. Kong X#, Gong Z#, Zhang L#, Sun X#, Ou Z, Xu B, Huang J, Long D, He X, Lin X, Li Q, Xu L, Xuan A*. JAK2/STAT3 signaling mediates IL-6-inhibited neurogenesis of neural stem cells through DNA demethylation/methylation. Brain Behav Immun. 2019;79:159-173. (IF= 19.227)
2. Ou Z#, Kong X#, Sun X#, He X#, Zhang L, Gong Z, Huang J, Xu B, Long D, Li J, Li Q, Xu L, Xuan A*. Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice. Brain Behav Immun. 2018;69:351-363. (IF= 19.227)
3. Ye X#, Wu Y#, Xu J#, Liu H#, Wang H, Li Q, Li Q, Xuan A*. PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation. Pharmacol Res. 2022;179:106235. (IF= 10.334)
4. Gong Z#, Huang J#, Xu B#, Ou Z#, Zhang L, Lin X, Ye X, Kong X, Long D, Sun X, He X, Xu L, Li Q, Xuan A*. Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice. J Neuroinflammation. 2019;16(1):62. (IF= 9.587)
5. Zhang X#, He X#, Li Q#, Kong X, Ou Z, Zhang L, Gong Z, Long D, Li J, Zhang M, Ji W, Zhang W, Xu L, Xuan A*. PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications. Stem Cell Reports. 2017;8(5):1256-1269. (IF= 7.765)
6. Zhang L#, Li Q#, Wang H#, Wu Y#, Ye X, Gong Z, Li Q, Xuan A*. Gadd45g, a novel antidepressant target, mediates metformin-induced neuronal differentiation of neural stem cells via DNA demethylation. Stem Cells, 2022,40(1):59-73. (IF= 7.871)
7. Xu B#, Li Q#, Wu Y#, Wang H#, Xu J, Liu H, Xuan A*. Mettl3-mediated m6A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects. FASEB J. 2022;36(7):e22392. (IF= 5.834)
8. Guan YF#, Huang GB#, Xu MD, Gao F, Lin S, Huang J, Wang J, Li YQ, Wu CH, Yao S, Wang Y, Zhang YL, Teoh JP, Xuan A*, Sun XD*. Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula. Brain Behav Immun. 2020;88:748-762. (IF= 19.227)
9. Lin XH#, Ye XJ#, Li QF, Gong Z, Cao X, Li JH, Zhao ST, Sun XD, He XS*, Xuan AG*. Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice. Neuroscience. 2020;448:94-106. (IF= 3.59)
10. Liao W, Luo H, Ruan Y, Mai Y, Liu C, Chen J, Yang S, Xuan A*, Liu J*. Identification of candidate genes associated with clinical onset of Alzheimer's disease. Front Neurosci. 2022;16:1060111. (IF= 5.151)
11. Li Q#, Wang X#, Wang ZH#, Lin Z, Yang J, Chen J, Wang R, Ye W, Li Y, Wu Y*, Xuan A*. Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice. Hum Vaccin Immunother. 2022 Sep 16:2121568. (IF= 4.525)
