所属学科：免疫学、病原生物学、生物化学与分子生物学
个人概况
姓 名：李美丽 性 别：女
最后学历：博士 技术职称：教授
导师层次：博士/硕士研究生导师，博士后合作导师
毕业院校：中国科学院武汉病毒研究所
单位：基础医学院广州霍夫曼免疫研究所病原生物学与免疫学教研室、附属第二医院广东省过敏反应与免疫重点实验室PI
电子邮件：1035579138@qq.com
研究方向
方向1：疱疹病毒感染致病机制研究
方向2：疱疹病毒感染与免疫逃逸
方向3：疱疹病毒疫苗研制、抗病毒药物研发与作用机制研究
方向4：EB病毒感染与肿瘤发生发展的关系
方向5：溶瘤病毒的作用机制与应用
方向6：病毒蛋白亚细胞转运转运机制及功能研究
方向7：宿主天然免疫调控机制研究
方向8：肿瘤免疫、抗肿瘤药物/疫苗研究
所获荣誉
1. 广东省高等学校优秀青年教师
2. 第五届广东医学科技奖二等奖
3. 广东省“千百十人才培养工程”第八批培养对象
4. 广州市珠江科技新星
5. 广州市高层次人才
6. 广州医科大学“南山学者”
7. 广州医科大学高水平大学学术骨干
8. 广州医科大学首批“青年骨干教师培养工程”培养对象
指导学生获得的科研项目和奖项
1. 指导本科生获得国家级、省级、市级和校级等科研项目和全国大学生基础医学创新研究暨实验设计论坛以及 “挑战杯”广东大学生课外学术科技作品竞赛奖项50余项。
2. 指导研究生获得研究生国家奖学金、优秀研究生称号、研究生企业奖学金和研究生学业奖学金等多种奖学金及科研立项。
社会兼职
1. 国家自然科学基金评审专家
2. 国家科技专家库和教育部科技评价与评审信息系统专家
3. 广东省/浙江省/湖南省自然科学基金评审专家
4. 广东省热带医学学会理事、广东省和湖北省免疫学会会员
5. 多个杂志审稿专家：Journal of Advanced Research、Biochimica Et Biophysica Acta-Molecular Cell Research、Virologica Sinica、Virulence、Cell Communication and Signaling、Computers in Biology and Medicine、Frontiers in Immunology、Frontiers in Cellular and Infection Microbiology、Frontiers in Veterinary Science、Journal of Basic Microbiology、Archives of Virology和Journal of Clinical Laboratory Analysis等
主持科研项目
主持国家级（国家自然科学基金）、省级（广东省自然科学基金）、厅级（广东省普通高校重点领域专项、广东省普通高校特色创新项目、广东省医学科研基金）、市级（广州市珠江科技新星专项、呼吸疾病国家重点实验室开放课题和广州市属高校科研项目）和校级（广州医科大学高水平大学学术骨干培养计划和广州医科大学博士启动项目）等多个级别科研项目20余项，研究经费充足。
部分代表性第一和通讯作者论文：
1) Mingsheng Cai, Bin Xiao, Yuanfang Wang, Kezhen Wang, Wenqi Luo, Jiangqin Fu, Shuai Wang, Shenyu Deng, Bolin Li, Lan Gong, Jiayi Zhong, Li Hu, Lingxia Pan, Liding Wang, Yintao Liu, Chen Huang, Xiaoqing Li, Qiyuan Zeng, Haoran Kang, Linhai Li, Jie Zan(*), Tao Peng(*), Haidi Yang(*),Meili Li(*). Epstein-Barr virus envelope glycoprotein 110 inhibits NF-κB activation by interacting with NF-κB subunit p65. Journal of Biological Chemistry, 2023, 299(5):104613. Nature index
2) Yingjie Guo, Lingxia Pan, Liding Wang, Shuai Wang, Jiangqin Fu, Wenqi Luo, Kezhen Wang, Xiaoqing Li, Chen Huang, Yintao Liu, Haoran Kang, Qiyuan Zeng, Xiuxia Fu, Zejin Huang, Wanying Li, Yingxin He, Linhai Li, Tao Peng, Haidi Yang(*), Meili Li(*), Bin Xiao(*), Mingsheng Cai(*). Epstein-Barr virus envelope glycoprotein gp110 inhibits IKKi-mediated activation of NF-κB and promotes the degradation of β-catenin. Microbiology Spectrum, 2023, 11(3): e0032623.
3) Zhiyong Yu, Linbo Zheng, Yan Geng, Yuting Zhang, Yupeng Wang, Guoxing You, Mingsheng Cai, Meili Li(*), Xiao Cheng(*), Jie Zan(*). FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner. Cellular Signalling, 2023, 109: 110751.
4) Lan Gong, Xiaowen Ou, Li Hu, Jiayi Zhong, Jingjing Li, Shenyu Deng, Bolin Li, Lingxia Pan, Liding Wang, Xuejun Hong, Wenqi Luo, Qiyuan Zeng, Jie Zan, Tao Peng(*), Mingsheng Cai(*), Meili Li(*). The molecular mechanism of herpes simplex virus 1 UL31 in antagonizing the activity of IFN-β. Microbiology Spectrum, 2022, 10(1): e01883-21.
5) Jingjing Li, Yingjie Guo, Yangxi Deng, Li Hu, Bolin Li, Shenyu Deng, Jiayi Zhong, Li Xie, Shaoxuan Shi, Xuejun Hong, Xuelong Zheng, Mingsheng Cai(*), Meili Li(*). Subcellular localization of Epstein-Barr virus BLLF2 and its underlying mechanisms. Frontiers in Microbiology, 2021,12:672192.
6) Ping Wang, Yangxi Deng, Yingjie Guo, Zuo Xu, Yiwen Li, Xiaowen Ou, Li Xie, Manjiao Lu, Jiayi Zhong, Bolin Li, Li Hu, Shenyu Deng, Tao Peng, Mingsheng Cai(*), Meili Li(*). Epstein-Barr virus early protein BFRF1 suppresses IFN-β activity by inhibiting the activation of IRF3. Frontiers in Immunology, 2020, 11:513383.
7) Meili Li, Shuai Wang, Mingsheng Cai, Chunfu Zheng(*). Identification of nuclear and nucleolar localization signals of pseudorabies virus (PRV) early protein UL54 reveals that its nuclear targeting is required for efficient production of PRV. Journal of Virology, 2011, 85(19): 10239-10251.
8) Mingsheng Cai, Zongmin Liao, Xingmei Zou, Zuo Xu, Yuanfang Wang, Tong Li, Yiwen Li, Xiaowen Ou, Yangxi Deng, Yingjie Guo, Tao Peng, Meili Li(*). Herpes simplex virus 1 UL2 inhibits the TNF-α-mediated NF-κB activity by interacting with p65/p50. Frontiers in Immunology, 2020, 11:549.
9) Tao Chen, Yuanfang Wang, Zuo Xu, Xingmei Zou, Ping Wang, Xiaowen Ou, Yiwen Li, Tao Peng, Daixiong Chen, Meili Li(*), Mingsheng Cai(*). Epstein-Barr virus tegument protein BGLF2 inhibits NF-kB activity by preventing p65 Ser536 phosphorylation. FASEB Journal, 2019, 33(9):10563-10576.
10) Meili Li, Zongmin Liao, Zuo Xu, Xingmei Zou, Yuanfang Wang, Hao Peng, Yiwen Li, Xiaowen Ou, Yangxi Deng, Yingjie Guo, Weidong Gan, Tao Peng, Daixiong Chen, Mingsheng Cai(*). The interaction mechanism between herpes simplex virus 1 glycoprotein D and host antiviral protein viperin. Frontiers in Immunology, 2019, 10: 2810.
11) Mingsheng Cai, Si Jiang, Zhancheng Zeng, Xiaowei Li, Chuncong Mo, Yanjia Yang, Chunke Chen, Peiping Xie, Yun Bian, Jinlin Wang, Jinlu Huang, Daixiong Chen, Tao Peng, Meili Li(*). Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22. Cell & Bioscience, 2016, 6: 3.
12) Mingsheng Cai, Shuxuan Deng, Meili Li(*). Comparison of the immune responses in BALB/c Mice following immunization with DNA-based and live attenuated vaccines delivered via different routes. Vaccine, 2013, 31(9): 1353-1356.
13) Meili Li, Shuai Wang, Mingsheng Cai, Hong Guo, Chunfu Zheng(*). Characterization of molecular determinants for nucleocytoplasmic shuttling of PRV UL54. Virology, 2011, 417(2): 385-393.
14) Mingsheng Cai#, Meili Li#, Chunfu Zheng(*). Herpesviral infection and Toll-like receptor 2. Protein & Cell, 2012, 3(8): 590-601.
15) Meili Li, Si Jiang, Chuncong Mo, Zhancheng Zeng, Xiaowei Li, Chunke Chen, Yanjia Yang, Jinlin Wang, Jinlu Huang, Daixiong Chen, Tao Peng, Mingsheng Cai(*). Identification of molecular determinants for the nuclear import of pseudorabies virus UL31. Archives of Biochemistry and Biophysics, 2015, 587:12-17.
16) Mingsheng Cai, Zhiyao Zhao, Wei Cui, Lin Yang, Junyi Zhu, Yalan Chen, Changling Ma, Zhuqing Yuan, Meili Li(*). Molecular properties of the Epstein-Barr virus BFRF3 gene. Virologica Sinica, 2013, 28(6): 368-372.
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