二级学科：免疫学
个人概况
姓 名：黄俊 性 别：男
民 族：汉 导师层次：博导
技术职称：教授 导师类型：学术型
最后学历：博士 最后学位：博士
工作单位：病原生物学与免疫学教研室
邮箱：630427062@qq.com
研究方向
抗感染免疫；天然免疫
所获荣誉
1. 广州市科技局“科技新星”
2. 广东省科技进步三等奖（排名第二）
社会兼职
1. 广东省免疫学会副理事长
2. 广东省寄生虫学会理事
3. 广东省科普促进会临床免疫分会主任委员
4. 《热带医学杂志》编辑
主持科研项目
主持国家级
1. 国家自然科学基金面上项目，82271798，TLR7调节ICOS+B细胞在约氏疟原虫NSM感染过程中的作用及机制，2023.1.1-2026.12.31，52万，主持
2. 国家自然科学基金面上项目，81771696，疟原虫感染在肺脏诱导的γδTCR+髓系细胞的研究，2018.1-2021.12，56万，已结题，主持
3. 国家自然科学基金青年项目，30901353，Th17细胞对日本血吸虫虫卵肉芽肿及肝纤维化的作用，2010.01-2012.12，20万，已结题，主持
省级
4. 广东省自然科学基金项目，2024A1515010849，疟原虫感染诱导的"记忆样"NK细胞的特点及机制的研究，2024.1-2026.12, 15万，，主持
5. 广东省自然科学基金，2021A1515011032, TLR7/KPNA2信号通路在血吸虫感染诱导B细胞活化分化中的作用，2021.1-2024.1, 10万,已结题，主持
6. 广东省自然科学基金，2020A1515010251，TLR+B细胞在日本血吸虫肝肉芽肿形成中的作用及机制，2019.10.1-2022.9.30, 10万,已结题，主持
7. 广东省医学科研基金，A2015436，Ⅰ型登革病毒诱导的记忆性T细胞的特征，2015.7-2017.6，0.5万，已结题，主持
8. 广东省自然科学基金博士启动资金，093008，Th17细胞对日本血吸虫虫卵肉芽肿及肝纤维化形成的影响，2008.10-2010.09，3万，已结题，主持
市厅级
1. 广州市科技计划项目，202002030082, γδT细胞在疟原虫诱导小鼠病变过程中的作用及机制研究，2020.4.1-2023.3.31, 20万，已结题，主持
2. 广东省教育厅重大项目，2016KZDXM033，γδT细胞在日本血吸虫感染小鼠肝免疫微环境中的作用，2017.1-2019.12，50万，已结题，主持
3. 广州市科技局科技新星项目，2011J2200007，Th9细胞对日本血吸虫虫卵肉芽肿及纤维化的影响，2011.11-2014.10， 30万，已结题，主持
部分代表性第一和通讯作者论文：
1. Quan Yang1,2,3,4,#*, Lu Zhou1, 2,#, Zhengrong Tan1, 2,#, Yiqiang Zhu2, lengshan Mo2, Chao Fang2, Jiajie Li2, Chen Chen1, Ying Luo1, Haixia Wei1,2,3, Weiguo Yin*,1, Jun Huang1,2,3,* TLR7 enhancing follicular helper T (Tfh) cells response in C57BL/6 mice infected with Plasmodium yoelii NSM. Immunology, 2024, 171:413–427.
2. Jiajie Li1,#, Lin Liu1,#, Junmin Xing2,#, Dianhui Chen1, Cao Fang2, Feng Mo1,Yumei Gong2, Zhengrong Tan2, Haixia Wei2, Shan Zhao2, Hongyan Xie2, Xingfei Pan1,*, Xiaomao Yin3, and Jun Huang2,4,5,*. TLR7 modulates extramedullary splenic erythropoiesis in P. yoelii NSM-infected mice by regulating the iron metabolism of macrophages with IFN-γ. Frontiers in Immunology. 2023 April 27: 1123074.
3. Jiajie Li1,2, Lin Liu2, Dianhui Chen3, Weiguo Yin1 and Jun Huang2. Trained immunity from the perspective of Plasmodium infection. Eur. J. Immunol. 2023 Jun;53(6):e2250268.
4. Haixia Wei1,2#, Anqi Xie2#, Jiajie Li2#, Chao Fang2#, Lin Liu2, Junmin Xing2, Feihu Shi1, Feng Mo1, Dianhui Chen1,2, Hongyan Xie2, Quan Yang2, Xingfei Pan1*, Xiaoping Tang3* and Jun Huang2*. PD-1+ CD4 T cell immune response is mediated by HIF-1a/NFATc1 pathway after P. yoelii infection. Frontiers in Immunology. 2022.942862.
5. Hongyan Xie1,#, Shihao Xie1,#, Mei Wang1,#, Haixia Wei1, He Huang1, Anqi Xie1, Jiajie Li1, Chao Fang1, Feihu Shi1, 3, Quan Yang1, Yanwei Qi1, Zhinan Yin2,3, Xinhua Wang1,*, and Jun Huang1,4*. Properties and roles of γδT cells in Plasmodium yoelii nigeriensis NSM infected C57BL/6 mice. Frontiers in Cellular and Infection Microbiology, 2022.1:788546.
6. Haixia Wei1#, Hongyan Xie1#, Jiale Qu1, Anqi Xie1, Shihao Xie1, He Huang1, Jiajie Li1, Chao Fang1, Feihu Shi1, Huaina Qiu1, Yanwei Qi1, Xu Tian2*, Quan Yang1*, Jun Huang1,3*. TLR7 modulating B-cell immune responses in the spleen of C57BL/6 mice infected with Schistosoma japonicum. PLoS Negl Trop Dis. 2021 Nov 17;15(11):e0009943.
7. Yuanfa Feng1,2†, Hongyan Xie2†, Feihu Shi 1†, Dianhui Chen1,2, Anqi Xie2, Jiajie Li 2, Chao Fang2, Haixia Wei 2, He Huang2, Xingfei Pan1*, Xiaoping Tang3* and Jun Huang2*. Roles of TLR7 in Schistosoma japonicum infection induced liver damage. Frontiers in Cellular and Infection Microbiology, 2021.10, 11, 754299.
8. Shihao Xie 1#,Haixia Wei 2,#, Anping Peng3,#, Anqi Xie2, Jiajie Li2, Chao Fang1, Feihu Shi1, Quan Yang2, He Huang2, Hongyan Xie2, Xingfei Pan 1,*, Xu Tian 2,4,*, and Jun Huang2,5,*. Ikzf2 regulates the development of ICOS+ Th Cells to mediate immune response in the spleen of S. japonicum infected C57BL/6 mice. Frontiers in Immunology. 2021.8, 12, 687919.
9. Quan Yang 1,2*#, Hongyan Xie 1#, Xing Li 3, Yuanfa Feng 1, Shihao Xie 1, Jiale Qu 1, Anqi Xie 1, Yiqiang Zhu 1, Lu Zhou 1, Jinxue Yang 1, Xiaohao Hu 1, Haixia Wei1, Huaina Qiu 1, Wenjuan Qin 4*, and Jun Huang 1,2*. Interferon regulatory factor 4 regulates the development of polymorphonuclear myeloid-derived suppressor cells through the transcription of c-Myc in cancer. Frontiers in Immunology. 2021.1, 12,627072.
10. Hefei Cha1, #, Hongyan Xie1, #, Chenxi Jin1, #, Yuanfa Feng1,#, Shihao Xie1, Anqi Xie1, Quan Yang1, Yanwei Qi1, Huaina Qiu1, Qiongli wu2, Zhinan Yin3, Jianbing Mu4, *, Jun Huang1,*. Adjustments of γδ T cells in the lung of Schistosoma japonicum-infected C56BL/6 mice. Frontiers in Immunology. 2020.6, 11:1045. (IF=7.802)
11. Jiale Qu1, †, Xiuxue Yu1, †, Chenxi Jin1, †, Yuanfa Feng1, Shihao Xie1, Hongyan Xie1, Quan Yang1, Yanwei Qi1, Huaina Qiu1, Hongyuan Chen2, Yi Zhou3, * and Jun Huang1, *. TLR7 Modulated T Cell Response in the Mesenteric Lymph Node of Schistosoma japonicum-Infected C57BL/6 Mice. Journal of Immunology Research. 2019.12，2019: 2691808.
12. Quan Yang #, Jiale Qu #, Chenxi Jin, Yuanfa Feng, Shihao Xie, Jinxin Zhu, Gaoshen Liu, Hongyan Xie, Huaina Qiu ,Yanwei Qi, Jiangbing Mu*, Jun Huang*. Schistosoma japonicum infection promotes the accumulation of Tfh cells through down-regulation of caspase-3–mediating apoptosis. Frontiers in Immunology. 2019, 10: 2154.
