个人简介

    马宁芳，人体解剖与组织胚胎学博士，教授，博士生导师，广东省南粤优秀教师。兼任教育部高等学校教学指导委员会委员（基础医学），中国解剖学会理事会组织胚胎学专业委员会常务理事、广东省解剖学会副理事长。

  所在单位：广州医科大学基础医学院

  研究方向：细胞异常分化与肿瘤发生

  主持科研项目

1. 国家自然科学基金项目：新肝癌相关基因ALC1对β-catenin的调控作用及其分子机制研究（批准号30872508

2. 国家自然科学基金项目: chd1l在精原干细胞自我更新和分化中的作用及分子机制(81170623)

3. 广东省自然科学基金项目： miRNAs介导的ALC1转录后调控对干细胞样肝癌细胞恶性表型的抑制作用研究（2017A030313562）

4. 广州市 “羊城学者”项目: ALC1基因对肝癌干细胞的干性维持作用及其分子调控 (12A016G)

5. 广州市科技计划项目:  c-MYC-Chd1l反馈环路富集EGF/EFGR信号促进肝癌细胞恶性表型进展的分子机制（2018040100160）

6. 广州市科技计划项目： EifA2与肿瘤转移的相关性研究 （61053）

  研究论文

1. Xiaofeng Zhang#，Yinshan Bai, Li Huang, Shanshan Liu, Yanxuan Mo, Wei Cheng, Guangliang Wang, Zhiming Cao, Xiaogang Chen, Huiqing Cui, Ling Qi, Lei Ma, Ming Liu, Xin-Yuan Guan and Ning-Fang Ma*. CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3. Cell Death Dis. 2021 Oct; 12(10): 950.

2. Guangliang Wang#, Xiaofeng Zhang#, Wei Cheng, Yanxuan Mo, Juan Chen, Zhiming Cao, Xiaogang Chen, Huiqin Cui, Shanshan Liu, Li Huang, Ming Liu, Lei Ma, Ning-Fang Ma*. CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis. Cell Death Dis. 2021 Oct; 12(10): 891.

3. Xiao-Dong Yang^#, Fan-En Kong^#, Ling Qi^#, Jia-Xin Lin^#, Qian Yan, Jane Ho Chun Loong, Shao-Yan Xi, Yue Zhao, Yan Zhang, Yun-Fei Yuan, Ning-Fang Ma, Stephanie Ma, Xin-Yuan Guan, and Ming Liu*. PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma. Mol Cancer. 2021; 20: 20. doi: 10.1186/s12943-021-01315-9

4. Wei Cheng, Hao-Long Li, Shao-Yan Xi, Xiao-Feng Zhang, Yun Zhu, Le Xing, Yan-Xuan Mo, Mei-Mei Li, Fan-En Kong, Wen-Jie Zhu, Xiao-Gang Chen, Hui-Qing Cui, Zhi-Ming Cao, Yuan-Feng Gong, Yun-Qiang Tang, Yan Zhang, Xin-Yuan Guan, Ning-Fang Ma, Ming Liu*. Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma. Nat Commun. 2021; 12: 7142. doi: 10.1038/s41467-021-27525-9

5. Liu SS, Maguire EM, Bai YS, Huang L, Liu Y, Xu L, Fauzi I, Zhang SQ, Xiao Q*, Ma NF*. A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties. Mol Cell Biol. 2019 Feb 4;39(4). pii: e00357-18.

6. Xiaohui Zhao, Tian Xie, Ting Dai,Wenhui Zhao, Jing Li, Rui Xu, Chao Jiang,Peiqiong Li, Junyao Deng, Xiaobo Su* and Ningfang Ma*. CHP2 Promotes Cell Proliferation in Breast Cancer via Suppression of FOXO3a. Mol Cancer Res. 2018 Oct;16(10):1512-1522.

7. Liu SS, Bai YS, Feng L, Dong WW, Li Y, Xu LP, Ma NF*. Identification of CHD1L as an Important Regulator for Spermatogonial Stem Cell Survival and Self-Renewal. Stem Cells Int. 2016; 2016:4069543.

8. Bai Y, Feng M, Liu S, Wei H, Li L, Zhang X, Shen C, Zhang S*, Ma N*. Differential gene expression in mouse spermatogonial stem cells and embryonic stem cells. Int J Mol Med. 2016;38(2):423-32.

9. Liu M, Chen L, Ma NF, Chow RK, Li Y, Song Y, Chan TH, Fang S, Yang X, Xi S, Jiang L, Li Y, Zeng TT, Li Y, Yuan YF, Guan XY. CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors. Hepatology. 2016; 63(5):1544-59.

10. Xuan Li, Xiao-Qi Wu, Rong Deng, Dan-Dan Li, Jun Tang, Wen-Dan Chen, Jing-Hong Chen, Jiao Ji, Lin Jiao, Shan Jiang, Fen Yang, Gong-Kan Feng, Ravichandran Senthilkumar, Fei Yue, Hai-Liang Zhang, Rui-Yan Wu, Yan Yu, Xue-Lian Xu, Jia Mai, Zhi-Ling Li, Xiao-Dan Peng, Yun Huang, Xiang Huang, Ning-Fang Ma, Qian Tao, Yi-Xin Zeng & Xiao-Feng Zhu. CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation. Nature Communications, 2017;8(1):1159.

11. Zhu X, Huang L, Gong J, Shi C, Wang Z, Ye B, Xuan A, He X, Long D, Zhu X, Ma N, Leng S. NF-κB pathway link with ER stress-induced autophagy and apoptosis in cervical tumor cells. Cell Death Discov. 2017; 3:17059.

12. Tang DJ, Dong SS, Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY. Over expression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. Hepatology, 2010; 51(4):1255--63.

13. Ning-Fang Ma, Sze Hang Lau, Liang Hu, Dan Xie, Jun Wu, Jun Yang, Yi Wang, Meng-Chao Wu, Jackie Fung, Xueyan Bai, Chi-Hung Tzang, Mengsu Yang, Yan An Su, Xin-Yuan Guan. Association of HBV X protein with the development of hepatocellular carcinoma. Clinical Cancer Research，2008; 14(16):5061-5068

14. Ma NF^#1, Hu L^#1, Fung JM, Xie D, Zheng BJ, Chen L, Tang DJ, Fu L, Wu Z, Chen M, Fang Y, Guan XY. Isolation and characterization of a novel oncogene ALC1 within a commonly amplified region at 1q21 in hepatocellular carcinoma. Hepatology, 2008;47(2):503-510.